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The Role of Nuclear-Encoded Mitochondrial tRNA Charging Enzymes in Human Inherited Disease
Aminoacyl-tRNA synthetases (ARSs) are highly conserved essential enzymes that charge tRNA with cognate amino acids—the first step of protein synthesis. Of the 37 nuclear-encoded human ARS genes, 17 encode enzymes are exclusively targeted to the mitochondria (mt-ARSs). Mutations in nuclear mt-ARS gen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777667/ https://www.ncbi.nlm.nih.gov/pubmed/36553587 http://dx.doi.org/10.3390/genes13122319 |