Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence

Gout is caused by elevated serum urate leading to the deposition of monosodium urate (MSU) crystals that can trigger episodes of acute inflammation. Humans are sensitive to developing gout because they lack a functional urate-metabolizing enzyme called uricase/urate oxidase (encoded by the UOX gene)...

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Detalles Bibliográficos
Autores principales: Linnerz, Tanja, Sung, Yih Jian, Rolland, Leah, Astin, Jonathan W., Dalbeth, Nicola, Hall, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777727/
https://www.ncbi.nlm.nih.gov/pubmed/36553446
http://dx.doi.org/10.3390/genes13122179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777727/
https://www.ncbi.nlm.nih.gov/pubmed/36553446
http://dx.doi.org/10.3390/genes13122179

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