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Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes

Edible, plant-derived foodstuffs are recognized as precious sources of polyphenol compounds, whose consumption has proven to have multiple beneficial effects on human health. However, the awareness that cooking processes are able to induce quali-quantitatively changes in their native occurrence and...

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Autores principales: Brahmi-Chendouh, Nabila, Piccolella, Simona, Gravina, Claudia, Fiorentino, Marika, Formato, Marialuisa, Kheyar, Naoual, Pacifico, Severina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777799/
https://www.ncbi.nlm.nih.gov/pubmed/36553698
http://dx.doi.org/10.3390/foods11243955
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author Brahmi-Chendouh, Nabila
Piccolella, Simona
Gravina, Claudia
Fiorentino, Marika
Formato, Marialuisa
Kheyar, Naoual
Pacifico, Severina
author_facet Brahmi-Chendouh, Nabila
Piccolella, Simona
Gravina, Claudia
Fiorentino, Marika
Formato, Marialuisa
Kheyar, Naoual
Pacifico, Severina
author_sort Brahmi-Chendouh, Nabila
collection PubMed
description Edible, plant-derived foodstuffs are recognized as precious sources of polyphenol compounds, whose consumption has proven to have multiple beneficial effects on human health. However, the awareness that cooking processes are able to induce quali-quantitatively changes in their native occurrence and that their bioavailability after food ingestion is poor led the research to move toward the preparation of nutraceutical supplements aimed at maximizing their content by effective extractive techniques and protecting them from degradation. The present work fits into this context, proposing a green, ready-to-use formulation of capitula, stems, and leaves of Algerian artichokes, in which natural deep eutectic solvents were exploited as extracting solvents but not removed at the end of the process. MTT test on the Caco-2 cell line highlighted that mitochondrial redox activity inhibition was absent below the 50 µg/mL tested dose. Simulated in vitro digestion was used as a predictive model for formulation bioaccessibility, where the joint approach with UHPLC-HRMS techniques allowed to define the release of each polyphenol from the investigated matrices. The capitula-based sample was the richest one in flavonoids, especially luteolin and apigenin glycosides, which survived in the intestinal digesta. On the contrary, simple phenols characterized the stem sample, whose release was mainly in the gastric chyme.
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spelling pubmed-97777992022-12-23 Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes Brahmi-Chendouh, Nabila Piccolella, Simona Gravina, Claudia Fiorentino, Marika Formato, Marialuisa Kheyar, Naoual Pacifico, Severina Foods Article Edible, plant-derived foodstuffs are recognized as precious sources of polyphenol compounds, whose consumption has proven to have multiple beneficial effects on human health. However, the awareness that cooking processes are able to induce quali-quantitatively changes in their native occurrence and that their bioavailability after food ingestion is poor led the research to move toward the preparation of nutraceutical supplements aimed at maximizing their content by effective extractive techniques and protecting them from degradation. The present work fits into this context, proposing a green, ready-to-use formulation of capitula, stems, and leaves of Algerian artichokes, in which natural deep eutectic solvents were exploited as extracting solvents but not removed at the end of the process. MTT test on the Caco-2 cell line highlighted that mitochondrial redox activity inhibition was absent below the 50 µg/mL tested dose. Simulated in vitro digestion was used as a predictive model for formulation bioaccessibility, where the joint approach with UHPLC-HRMS techniques allowed to define the release of each polyphenol from the investigated matrices. The capitula-based sample was the richest one in flavonoids, especially luteolin and apigenin glycosides, which survived in the intestinal digesta. On the contrary, simple phenols characterized the stem sample, whose release was mainly in the gastric chyme. MDPI 2022-12-07 /pmc/articles/PMC9777799/ /pubmed/36553698 http://dx.doi.org/10.3390/foods11243955 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brahmi-Chendouh, Nabila
Piccolella, Simona
Gravina, Claudia
Fiorentino, Marika
Formato, Marialuisa
Kheyar, Naoual
Pacifico, Severina
Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes
title Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes
title_full Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes
title_fullStr Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes
title_full_unstemmed Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes
title_short Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes
title_sort ready-to-use nutraceutical formulations from edible and waste organs of algerian artichokes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777799/
https://www.ncbi.nlm.nih.gov/pubmed/36553698
http://dx.doi.org/10.3390/foods11243955
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