Unaffected Li-Fraumeni Syndrome Carrier Parent Demonstrates Allele-Specific mRNA Stabilization of Wild-Type TP53 Compared to Affected Offspring

Li-Fraumeni Syndrome (LFS) is an autosomal dominant disorder where an oncogenic TP53 germline mutation is inherited by offspring of a carrier parent. p53 is a key tumor suppressor regulating cell cycle arrest in response to DNA damage. Unexpectedly, some mutant TP53 carriers remain unaffected, while...

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Detalles Bibliográficos
Autores principales: Buzby, Jeffrey S., Williams, Shirley A., Nugent, Diane J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778056/
https://www.ncbi.nlm.nih.gov/pubmed/36553570
http://dx.doi.org/10.3390/genes13122302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778056/
https://www.ncbi.nlm.nih.gov/pubmed/36553570
http://dx.doi.org/10.3390/genes13122302

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