The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613

Variants in the CES1 gene encoding carboxylesterase 1 may affect the metabolism of enalapril to the active metabolite enalaprilat. It was shown that the A allele of rs71647871 and the C allele of rs2244613 led to a decrease in plasma enalaprilat concentrations. This study aimed to estimate the effec...

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Detalles Bibliográficos
Autores principales: Ikonnikova, Anna, Kazakov, Ruslan, Rodina, Tatiana, Dmitriev, Artem, Melnikov, Evgeniy, Zasedatelev, Alexander, Nasedkina, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778508/
https://www.ncbi.nlm.nih.gov/pubmed/36553492
http://dx.doi.org/10.3390/genes13122225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778508/
https://www.ncbi.nlm.nih.gov/pubmed/36553492
http://dx.doi.org/10.3390/genes13122225

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