Anticancer Activity, Reduction Mechanism and G-Quadruplex DNA Binding of a Redox-Activated Platinum(IV)–Salphen Complex

Aiming at reducing the unselective cytotoxicity of Pt(II) chemotherapeutics, a great deal of effort has been concentrated into the design of metal-containing drugs with different anticancer mechanisms of action. Inert Pt(IV) prodrugs have been proposed to be a valid alternative as they are activated...

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Detalles Bibliográficos
Autores principales: Vigna, Vincenzo, Scoditti, Stefano, Spinello, Angelo, Mazzone, Gloria, Sicilia, Emilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778786/
https://www.ncbi.nlm.nih.gov/pubmed/36555221
http://dx.doi.org/10.3390/ijms232415579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778786/
https://www.ncbi.nlm.nih.gov/pubmed/36555221
http://dx.doi.org/10.3390/ijms232415579

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