Elevation of Anticancer Drug Toxicity by Caffeine in Spheroid Model of Human Lung Adenocarcinoma A549 Cells Mediated by Reduction in Claudin-2 and Nrf2 Expression

Claudin-2 (CLDN2), a component of tight junctions, is abnormally expressed in human lung adenocarcinoma tissue. CLDN2 contributes to chemoresistance in human lung adenocarcinoma-derived A549 cells, and it may be a target for cancer therapy. Here, we found that coffee ingredients, namely caffeine and...

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Detalles Bibliográficos
Autores principales: Eguchi, Hiroaki, Kimura, Riho, Onuma, Saki, Ito, Ayaka, Yu, Yaqing, Yoshino, Yuta, Matsunaga, Toshiyuki, Endo, Satoshi, Ikari, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779108/
https://www.ncbi.nlm.nih.gov/pubmed/36555089
http://dx.doi.org/10.3390/ijms232415447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779108/
https://www.ncbi.nlm.nih.gov/pubmed/36555089
http://dx.doi.org/10.3390/ijms232415447

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