Normal Pregnancy-Induced Islet Beta Cell Proliferation in Mouse Models That Are Deficient in Serotonin-Signaling

During mouse pregnancy placental lactogens stimulate prolactin receptors on pancreatic islet beta cells to induce expression of the tryptophan hydroxylase Tph1, resulting in the synthesis and secretion of serotonin. Presently, the functional relevance of this phenomenon is unclear. One hypothesis is...

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Detalles Bibliográficos
Autores principales: Goyvaerts, Lotte, Schraenen, Anica, Lemaire, Katleen, Veld, Peter in’t, Smolders, Ilse, Maroteaux, Luc, Schuit, Frans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779327/
https://www.ncbi.nlm.nih.gov/pubmed/36555462
http://dx.doi.org/10.3390/ijms232415816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779327/
https://www.ncbi.nlm.nih.gov/pubmed/36555462
http://dx.doi.org/10.3390/ijms232415816

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