SARS-CoV-2 Spike Protein Mutation at Cysteine-488 Impairs Its Golgi Localization and Intracellular S1/S2 Processing

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds to the cellular receptor—angiotensin-converting enzyme-2 (ACE2) as the first step in viral cell entry. SARS-CoV-2 spike protein expression in the ACE2-expressing cell surface induces cell–cell membrane fusion, thus...

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Detalles Bibliográficos
Autores principales: Yamamoto, Yuichiro, Inoue, Tetsuya, Inoue, Miyu, Murae, Mana, Fukasawa, Masayoshi, Kaneko, Mika K., Kato, Yukinari, Noguchi, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779352/
https://www.ncbi.nlm.nih.gov/pubmed/36555473
http://dx.doi.org/10.3390/ijms232415834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779352/
https://www.ncbi.nlm.nih.gov/pubmed/36555473
http://dx.doi.org/10.3390/ijms232415834

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