The J Domain of Sacsin Disrupts Intermediate Filament Assembly

Autosomal Recessive Spastic Ataxia of the Charlevoix Saguenay (ARSACS) is caused by mutation in the SACS gene resulting in loss of function of the protein sacsin. A key feature is the formation of abnormal bundles of neurofilaments (NF) in neurons and vimentin intermediate filaments (IF) in cultured...

Descripción completa

Detalles Bibliográficos
Autores principales: Dabbaghizadeh, Afrooz, Paré, Alexandre, Cheng-Boivin, Zacharie, Dagher, Robin, Minotti, Sandra, Dicaire, Marie-Josée, Brais, Bernard, Young, Jason C., Durham, Heather D., Gentil, Benoit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779362/
https://www.ncbi.nlm.nih.gov/pubmed/36555380
http://dx.doi.org/10.3390/ijms232415742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779362/
https://www.ncbi.nlm.nih.gov/pubmed/36555380
http://dx.doi.org/10.3390/ijms232415742

Ejemplares similares