ONC201-Induced Mitochondrial Dysfunction, Senescence-like Phenotype, and Sensitization of Cultured BT474 Human Breast Cancer Cells to TRAIL

ONC201, the anticancer drug, targets and activates mitochondrial ATP-dependent caseinolytic peptidase P (ClpP), a serine protease located in the mitochondrial matrix. Given the promise of ONC201 in cancer treatment, we evaluated its effects on the breast ductal carcinoma cell line (BT474). We showed...

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Detalles Bibliográficos
Autores principales: Mishukov, Artem, Odinokova, Irina, Mndlyan, Ekaterina, Kobyakova, Margarita, Abdullaev, Serazhutdin, Zhalimov, Vitaly, Glukhova, Xenia, Galat, Vasiliy, Galat, Yekaterina, Senotov, Anatoly, Fadeev, Roman, Artykov, Artem, Gasparian, Marine E., Solovieva, Marina, Beletsky, Igor, Holmuhamedov, Ekhson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779726/
https://www.ncbi.nlm.nih.gov/pubmed/36555190
http://dx.doi.org/10.3390/ijms232415551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779726/
https://www.ncbi.nlm.nih.gov/pubmed/36555190
http://dx.doi.org/10.3390/ijms232415551

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