An Escherichia coli Expressed Multi-Disulfide Bonded SARS-CoV-2 RBD Shows Native-like Biophysical Properties and Elicits Neutralizing Antisera in a Mouse Model

A large-scale Escherichia coli (E. coli) production of the receptor-binding domain (RBD) of the SARS-CoV-2 could yield a versatile and low-cost antigen for a subunit vaccine. Appropriately folded antigens can potentially elicit the production of neutralizing antisera providing immune protection agai...

Descripción completa

Detalles Bibliográficos
Autores principales: Brindha, Subbaian, Yoshizue, Takahiro, Wongnak, Rawiwan, Takemae, Hitoshi, Oba, Mami, Mizutani, Tetsuya, Kuroda, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779815/
https://www.ncbi.nlm.nih.gov/pubmed/36555383
http://dx.doi.org/10.3390/ijms232415744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779815/
https://www.ncbi.nlm.nih.gov/pubmed/36555383
http://dx.doi.org/10.3390/ijms232415744

Ejemplares similares