Chemically Tuned Intracellular Gene Delivery by Core-Shell Nanoparticles: Effects of Proton Buffering, Acid Degradability, and Membrane Disruption

Nanoparticles consisting of a condensed nucleic acid core surrounded by protective layers which aid to overcome extracellular and intracellular hurdles to gene delivery (i.e., core-shell nanoparticles, CSNPs) synthetically mimic viruses. The outer shells shield the core and are particularly designed...

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Detalles Bibliográficos
Autores principales: Cho, Soo Kyung, Lee, Rebecca T., Hwang, Yoon-Hwae, Kwon, Young Jik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779904/
https://www.ncbi.nlm.nih.gov/pubmed/35060681
http://dx.doi.org/10.1002/cmdc.202100718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779904/
https://www.ncbi.nlm.nih.gov/pubmed/35060681
http://dx.doi.org/10.1002/cmdc.202100718

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