Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia

The genetics of relapsed pediatric acute myeloid leukemia (AML) has yet to be comprehensively defined. Here, we present the spectrum of genomic alterations in 136 relapsed pediatric AMLs. We identified recurrent exon 13 tandem duplications (TD) in upstream binding transcription factor (UBTF) in 9% o...

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Detalles Bibliográficos
Autores principales: Umeda, Masayuki, Ma, Jing, Huang, Benjamin J., Hagiwara, Kohei, Westover, Tamara, Abdelhamed, Sherif, Barajas, Juan M., Thomas, Melvin E., Walsh, Michael P., Song, Guangchun, Tian, Liqing, Liu, Yanling, Chen, Xiaolong, Kolekar, Pandurang, Tran, Quang, Foy, Scott G., Maciaszek, Jamie L., Kleist, Andrew B., Leonti, Amanda R., Ju, Bengsheng, Easton, John, Wu, Huiyun, Valentine, Virginia, Valentine, Marcus B., Liu, Yen-Chun, Ries, Rhonda E., Smith, Jenny L., Parganas, Evan, Iacobucci, Ilaria, Hiltenbrand, Ryan, Miller, Jonathan, Myers, Jason R., Rampersaud, Evadnie, Rahbarinia, Delaram, Rusch, Michael, Wu, Gang, Inaba, Hiroto, Wang, Yi-Cheng, Alonzo, Todd A., Downing, James R., Mullighan, Charles G., Pounds, Stanley, Babu, M. Madan, Zhang, Jinghui, Rubnitz, Jeffrey E., Meshinchi, Soheil, Ma, Xiaotu, Klco, Jeffery M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Briefs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780084/
https://www.ncbi.nlm.nih.gov/pubmed/35176137
http://dx.doi.org/10.1158/2643-3230.BCD-21-0160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780084/
https://www.ncbi.nlm.nih.gov/pubmed/35176137
http://dx.doi.org/10.1158/2643-3230.BCD-21-0160

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