Analysis of Complex Absorption After Multiple Dosing: Application to the Interaction Between the P-glycoprotein Substrate Talinolol and Rifampicin

PURPOSE: In order to clarify the effect of rifampicin on the bioavailability of the P-glycoprotein substrate talinolol, its absorption kinetics was modeled after multiple-dose oral administration of talinolol in healthy subjects. METHODS: A sum of two inverse Gaussian functions was used to calculate...

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Detalles Bibliográficos
Autores principales: Weiss, Michael, D’Argenio, David Z., Siegmund, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780127/
https://www.ncbi.nlm.nih.gov/pubmed/36163409
http://dx.doi.org/10.1007/s11095-022-03397-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780127/
https://www.ncbi.nlm.nih.gov/pubmed/36163409
http://dx.doi.org/10.1007/s11095-022-03397-6

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