Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates cofilin-1 on threonine 25 (phospho(T25)-cofilin-1) that in turn disassembles the actin cytoskeleton. Here, we show that in musc...

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Detalles Bibliográficos
Autores principales: Le Dour, Caroline, Chatzifrangkeskou, Maria, Macquart, Coline, Magiera, Maria M., Peccate, Cécile, Jouve, Charlène, Virtanen, Laura, Heliö, Tiina, Aalto-Setälä, Katriina, Crasto, Silvia, Cadot, Bruno, Cardoso, Déborah, Mougenot, Nathalie, Adesse, Daniel, Di Pasquale, Elisa, Hulot, Jean-Sébastien, Taimen, Pekka, Janke, Carsten, Muchir, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780334/
https://www.ncbi.nlm.nih.gov/pubmed/36550158
http://dx.doi.org/10.1038/s41467-022-35639-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780334/
https://www.ncbi.nlm.nih.gov/pubmed/36550158
http://dx.doi.org/10.1038/s41467-022-35639-x

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