Cargando…
Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration
Ensuring genome safety during gene editing is crucial for clinical translation of the high-efficient CRISPR-Cas9 toolbox. Therefore, the undesired events including chromosomal translocations, vector integrations, and large deletions arising during therapeutic gene editing remain to be adequately add...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780342/ https://www.ncbi.nlm.nih.gov/pubmed/36550137 http://dx.doi.org/10.1038/s41467-022-35640-4 |