Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration

Ensuring genome safety during gene editing is crucial for clinical translation of the high-efficient CRISPR-Cas9 toolbox. Therefore, the undesired events including chromosomal translocations, vector integrations, and large deletions arising during therapeutic gene editing remain to be adequately add...

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Detalles Bibliográficos
Autores principales: Yin, Jianhang, Fang, Kailun, Gao, Yanxia, Ou, Liqiong, Yuan, Shaopeng, Xin, Changchang, Wu, Weiwei, Wu, Wei-wei, Hong, Jiaxu, Yang, Hui, Hu, Jiazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780342/
https://www.ncbi.nlm.nih.gov/pubmed/36550137
http://dx.doi.org/10.1038/s41467-022-35640-4

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