Cargando…

Ophiopogonin D increase apoptosis by activating p53 via ribosomal protein L5 and L11 and inhibiting the expression of c-Myc via CNOT2

Ophiopogonin D (OP-D), which is extracted from the root tuber of Ophiopogon japonicus, is well known for its anti-inflammatory, anti-oxidant, and anti-cancer effects. It is also therapeutic for various diseases such as diabetic myocardial injuries, obesity, atopic dermatitis, and osteoporosis. Howev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ko, Hyun Min, Jee, Wona, Lee, Duckgue, Jang, Hyeung-Jin, Jung, Ji Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780504/ https://www.ncbi.nlm.nih.gov/pubmed/36569330 http://dx.doi.org/10.3389/fphar.2022.974468

Ejemplares similares

Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53
por: Jung, Ji Hoon, et al.
Publicado: (2021)

Momordicae Semen inhibits migration and induces apoptotic cell death by regulating c-Myc and CNOT2 in human pancreatic cancer cells
por: Jee, Wona, et al.
Publicado: (2023)

Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2
por: Jung, Ji Hoon, et al.
Publicado: (2020)

Antitumor Effect of Cycloastragenol in Colon Cancer Cells via p53 Activation
por: Park, Doil, et al.
Publicado: (2022)

Anti-Obesity Effect of Polygalin C Isolated from Polygala japonica Houtt. via Suppression of the Adipogenic and Lipogenic Factors in 3T3-L1 Adipocytes
por: Jee, Wona, et al.
Publicado: (2021)

Euonymus sachalinensis Induces Apoptosis by Inhibiting the Expression of c-Myc in Colon Cancer Cells
por: Park, So-Mi, et al.
Publicado: (2023)

Ribosomal Proteins L5 and L11 Cooperatively Inactivate c-Myc via RNA-induced Silencing Complex
por: Liao, Jun-Ming, et al.
Publicado: (2013)

The Antitumor Effect of Timosaponin A3 through c-Myc Inhibition in Colorectal Cancer Cells and Combined Treatment Effect with 5-FU or Doxorubicin
por: Ko, Hyun Min, et al.
Publicado: (2022)

The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
por: Mauxion, Fabienne, et al.
Publicado: (2022)

Rosa laevigata Attenuates Allergic Asthma Exacerbated by Water-Soluble PM by Downregulating the MAPK Pathway
por: Ko, Hyun Min, et al.
Publicado: (2022)

Isosinensetin Stimulates Glucagon-like Peptide-1 Secretion via Activation of hTAS2R50 and the G(βγ)-Mediated Signaling Pathway
por: Lee, Seung-Hyeon, et al.
Publicado: (2023)

Ginsenoside Rb1 and Rd Remarkably Inhibited the Hepatic Uptake of Ophiopogonin D in Shenmai Injection Mediated by OATPs/oatps
por: Liu, Xiaopei, et al.
Publicado: (2018)

p53-Dependent Apoptotic Effect of Puromycin via Binding of Ribosomal Protein L5 and L11 to MDM2 and Its Combination Effect with RITA or Doxorubicin
por: Jung, Ji Hoon, et al.
Publicado: (2019)

Role of Cnot6l in maternal mRNA turnover
por: Horvat, Filip, et al.
Publicado: (2018)

Global metabolomic and lipidomic analysis reveals the potential mechanisms of hemolysis effect of Ophiopogonin D and Ophiopogonin D' in vivo
por: Xu, Huan-Hua, et al.
Publicado: (2021)

Nucleolar Stress Response via Ribosomal Protein L11 Regulates Topoisomerase Inhibitor Sensitivity of P53-Intact Cancers
por: Ishihara, Yuka, et al.
Publicado: (2022)

Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications
por: Guo, Libin, et al.
Publicado: (2022)

Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling
por: Kim, Kang-Hoon, et al.
Publicado: (2018)

Loss of Cnot6l Impairs Inosine RNA Modifications in Mouse Oocytes
por: Brachova, Pavla, et al.
Publicado: (2021)

Ophiopogonin A Alleviates Hemorrhagic Shock-Induced Renal Injury via Induction of Nrf2 Expression
por: Sheng, Xiaoming, et al.
Publicado: (2021)

c-Myc-PD-L1 Axis Sustained Gemcitabine-Resistance in Pancreatic Cancer
por: Yao, Jingjing, et al.
Publicado: (2022)

Bafetinib Suppresses the Transcription of PD-L1 Through c-Myc in Lung Cancer
por: Chen, Xi, et al.
Publicado: (2022)

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
por: Zhong, Wang-Jing, et al.
Publicado: (2022)

Timosaponin A3 Inhibits Palmitate and Stearate through Suppression of SREBP-1 in Pancreatic Cancer
por: Kim, Yumi, et al.
Publicado: (2022)

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4–Not complex contribute to the prevention of cell death and senescence
por: Mittal, Saloni, et al.
Publicado: (2011)

Ophiopogonin D′, a Natural Product From Radix Ophiopogonis, Induces in Vitro and in Vivo RIPK1-Dependent and Caspase-Independent Apoptotic Death in Androgen-Independent Human Prostate Cancer Cells
por: Lu, Zongliang, et al.
Publicado: (2018)

Farnesiferol c induces apoptosis via regulation of L11 and c-Myc with combinational potential with anticancer drugs in non-small-cell lung cancers
por: Jung, Ji Hoon, et al.
Publicado: (2016)

Gancaonin N from Glycyrrhiza uralensis Attenuates the Inflammatory Response by Downregulating the NF-κB/MAPK Pathway on an Acute Pneumonia In Vitro Model
por: Ko, Hyun Min, et al.
Publicado: (2021)

The Anti-Proliferative Activity of BTG/TOB Proteins Is Mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) Deadenylase Subunits of the Ccr4-Not Complex
por: Doidge, Rachel, et al.
Publicado: (2012)

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation
por: Li, Yuhuang, et al.
Publicado: (2014)

FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development
por: Chioccarelli, Teresa, et al.
Publicado: (2021)

Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells
por: Han, Na-Ra, et al.
Publicado: (2023)

Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome
por: Qi, Yuekun, et al.
Publicado: (2017)

Effects of ophiopogonin B on the proliferation and apoptosis of SGC-7901 human gastric cancer cells
por: ZHANG, WEIYUE, et al.
Publicado: (2016)

Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway
por: Guo, Lin, et al.
Publicado: (2021)

Sunitinib induced hepatotoxicity in L02 cells via ROS-MAPKs signaling pathway
por: Tang, Ting-Li, et al.
Publicado: (2022)

Castor Oil Plant (Ricinus communis L.) Leaves Improve Dexamethasone-Induced Muscle Atrophy via Nrf2 Activation
por: Lee, Hyunjung, et al.
Publicado: (2022)

Ophiopogon Polysaccharide Promotes the In Vitro Metabolism of Ophiopogonins by Human Gut Microbiota
por: Wang, Huai-You, et al.
Publicado: (2019)

Antitumor Effects of Trimethylellagic Acid Isolated From Sanguisorba officinalis L. on Colorectal Cancer via Angiogenesis Inhibition and Apoptosis Induction
por: Bai, Chongfei, et al.
Publicado: (2020)

PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway
por: Li, Yulong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pctvtr21lcbob3oh1g0fud80q4