Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants

ABC transporters are large membrane proteins sharing a complex architecture, which comprises two nucleotide-binding domains (NBDs) and two membrane-spanning domains (MSDs). These domains are susceptible to mutations affecting their folding and assembly. In the CFTR (ABCC7) protein, a groove has been...

Descripción completa

Detalles Bibliográficos
Autores principales: Baatallah, Nesrine, Elbahnsi, Ahmad, Chevalier, Benoit, Castanier, Solène, Mornon, Jean-Paul, Pranke, Iwona, Edelman, Aleksander, Sermet-Gaudelus, Isabelle, Callebaut, Isabelle, Hinzpeter, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780841/
https://www.ncbi.nlm.nih.gov/pubmed/36555865
http://dx.doi.org/10.3390/ijms232416225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780841/
https://www.ncbi.nlm.nih.gov/pubmed/36555865
http://dx.doi.org/10.3390/ijms232416225

Ejemplares similares