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Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants

ABC transporters are large membrane proteins sharing a complex architecture, which comprises two nucleotide-binding domains (NBDs) and two membrane-spanning domains (MSDs). These domains are susceptible to mutations affecting their folding and assembly. In the CFTR (ABCC7) protein, a groove has been...

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Detalles Bibliográficos
Autores principales:	Baatallah, Nesrine, Elbahnsi, Ahmad, Chevalier, Benoit, Castanier, Solène, Mornon, Jean-Paul, Pranke, Iwona, Edelman, Aleksander, Sermet-Gaudelus, Isabelle, Callebaut, Isabelle, Hinzpeter, Alexandre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780841/ https://www.ncbi.nlm.nih.gov/pubmed/36555865 http://dx.doi.org/10.3390/ijms232416225

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