Analysis of Time-Dependent Pharmacokinetics Using In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Modeling

SCR430, a sorafenib derivative, is an investigational drug exhibiting anti-tumor action. This study aimed to have a mechanistic understanding of SCR430’s time-dependent pharmacokinetics (TDPK) through an ex vivo study combined with an in vitro–in vivo extrapolation (IVIVE) and physiologically based...

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Detalles Bibliográficos
Autores principales: Kim, Min-Chang, Lee, Young-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780873/
https://www.ncbi.nlm.nih.gov/pubmed/36559055
http://dx.doi.org/10.3390/pharmaceutics14122562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780873/
https://www.ncbi.nlm.nih.gov/pubmed/36559055
http://dx.doi.org/10.3390/pharmaceutics14122562

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