Rational-Based Discovery of Novel β-Carboline Derivatives as Potential Antimalarials: From In Silico Identification of Novel Targets to Inhibition of Experimental Cerebral Malaria

Malaria is an infectious disease widespread in underdeveloped tropical regions. The most severe form of infection is caused by Plasmodium falciparum, which can lead to development of cerebral malaria (CM) and is responsible for deaths and significant neurocognitive sequelae throughout life. In this...

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Detalles Bibliográficos
Autores principales: Alves, Fernanda de Moura, Bellei, Jessica Correa Bezerra, Barbosa, Camila de Souza, Duarte, Caíque Lopes, da Fonseca, Amanda Luisa, Pinto, Ana Claudia de Souza, Raimundo, Felipe Oliveira, Carpinter, Bárbara Albuquerque, Lemos, Ari Sérgio de Oliveira, Coimbra, Elaine Soares, Taranto, Alex Gutterres, Rocha, Vinícius Novaes, de Pilla Varotti, Fernando, Ribeiro Viana, Gustavo Henrique, Scopel, Kézia K. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781199/
https://www.ncbi.nlm.nih.gov/pubmed/36558863
http://dx.doi.org/10.3390/pathogens11121529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781199/
https://www.ncbi.nlm.nih.gov/pubmed/36558863
http://dx.doi.org/10.3390/pathogens11121529

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