Therapy of Organophosphate Poisoning via Intranasal Administration of 2-PAM-Loaded Chitosomes

Chitosan-decorated liposomes were proposed for the first time for the intranasal delivery of acetylcholinesterase (AChE) reactivator pralidoxime chloride (2-PAM) to the brain as a therapy for organophosphorus compounds (OPs) poisoning. Firstly, the chitosome composition based on phospholipids, chole...

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Detalles Bibliográficos
Autores principales: Vasilieva, Elmira A., Kuznetsova, Darya A., Valeeva, Farida G., Kuznetsov, Denis M., Zakharov, Andrey V., Amerhanova, Syumbelya K., Voloshina, Alexandra D., Zueva, Irina V., Petrov, Konstantin A., Zakharova, Lucia Ya.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781263/
https://www.ncbi.nlm.nih.gov/pubmed/36559339
http://dx.doi.org/10.3390/pharmaceutics14122846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781263/
https://www.ncbi.nlm.nih.gov/pubmed/36559339
http://dx.doi.org/10.3390/pharmaceutics14122846

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