Pharmacogenetic Dose Modeling Based on CYP2C19 Allelic Phenotypes

Pharmacogenetic variability in drug metabolism leads to patient vulnerability to side effects and to therapeutic failure. Our purpose was to introduce a systematic statistical methodology to estimate quantitative dose adjustments based on pharmacokinetic differences in pharmacogenetic subgroups, add...

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Detalles Bibliográficos
Autores principales: Stingl, Julia Carolin, Radermacher, Jason, Wozniak, Justyna, Viviani, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781550/
https://www.ncbi.nlm.nih.gov/pubmed/36559326
http://dx.doi.org/10.3390/pharmaceutics14122833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781550/
https://www.ncbi.nlm.nih.gov/pubmed/36559326
http://dx.doi.org/10.3390/pharmaceutics14122833

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