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Pharmacogenetic Dose Modeling Based on CYP2C19 Allelic Phenotypes
Pharmacogenetic variability in drug metabolism leads to patient vulnerability to side effects and to therapeutic failure. Our purpose was to introduce a systematic statistical methodology to estimate quantitative dose adjustments based on pharmacokinetic differences in pharmacogenetic subgroups, add...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781550/ https://www.ncbi.nlm.nih.gov/pubmed/36559326 http://dx.doi.org/10.3390/pharmaceutics14122833 |