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Pharmacogenetic Dose Modeling Based on CYP2C19 Allelic Phenotypes

Pharmacogenetic variability in drug metabolism leads to patient vulnerability to side effects and to therapeutic failure. Our purpose was to introduce a systematic statistical methodology to estimate quantitative dose adjustments based on pharmacokinetic differences in pharmacogenetic subgroups, add...

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Detalles Bibliográficos
Autores principales:	Stingl, Julia Carolin, Radermacher, Jason, Wozniak, Justyna, Viviani, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781550/ https://www.ncbi.nlm.nih.gov/pubmed/36559326 http://dx.doi.org/10.3390/pharmaceutics14122833

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