Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction

Toosendanin (TSN) is a triterpenoid from the fruit or bark of Melia toosendan Sieb et Zucc, which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity in clinical application. Autophagy is a degradation and recycling mechanism to maintain cellular homeostasis, an...

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Detalles Bibliográficos
Autores principales: Luo, Li, Liang, Yonghong, Fu, Yuanyuan, Liang, Zhiyuan, Zheng, Jinfen, Lan, Jie, Shen, Feihai, Huang, Zhiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781622/
https://www.ncbi.nlm.nih.gov/pubmed/36558960
http://dx.doi.org/10.3390/ph15121509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781622/
https://www.ncbi.nlm.nih.gov/pubmed/36558960
http://dx.doi.org/10.3390/ph15121509

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