A Single Amino Acid Substitution in Porcine Reproductive and Respiratory Syndrome Virus Glycoprotein 2 Significantly Impairs Its Infectivity in Macrophages

Porcine reproductive and respiratory syndrome virus (PRRSV) has a restricted tropism for macrophages and CD163 is a key receptor for infection. In this study, the PRRSV strain NCV1 was passaged on MARC-145 cells for 95 passages, and two plaque-clones (C1 and C2) were randomly selected for further an...

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Detalles Bibliográficos
Autores principales: Chaudhari, Jayeshbhai, Leme, Raquel Arruda, Durazo-Martinez, Kassandra, Sillman, Sarah, Workman, Aspen M., Vu, Hiep L. X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781675/
https://www.ncbi.nlm.nih.gov/pubmed/36560826
http://dx.doi.org/10.3390/v14122822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781675/
https://www.ncbi.nlm.nih.gov/pubmed/36560826
http://dx.doi.org/10.3390/v14122822

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