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Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules
Oligonucleotide therapeutics that can modulate gene expression have been gradually developed for clinical applications over several decades. However, rapid advances have been made in recent years. Artificial nucleic acid technology has overcome many challenges, such as (1) poor target affinity and s...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781680/ https://www.ncbi.nlm.nih.gov/pubmed/36559141 http://dx.doi.org/10.3390/pharmaceutics14122647 |