Chemical Modifications Influence the Number of siRNA Molecules Adsorbed on Gold Nanoparticles and the Efficiency of Downregulation of a Target Protein

Small interfering RNAs (siRNAs) are a powerful tool for specific suppression of protein synthesis in the cell, and this determines the attractiveness of siRNAs as a drug. Low resistance of siRNA to nucleases and inability to enter into target cells are the most crucial issues in developing siRNA-bas...

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Detalles Bibliográficos
Autores principales: Epanchintseva, Anna V., Poletaeva, Julia E., Dome, Anton S., Dovydenko, Ilya S., Pyshnaya, Inna A., Ryabchikova, Elena I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781748/
https://www.ncbi.nlm.nih.gov/pubmed/36558301
http://dx.doi.org/10.3390/nano12244450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781748/
https://www.ncbi.nlm.nih.gov/pubmed/36558301
http://dx.doi.org/10.3390/nano12244450

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