Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors

Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electrophiles: the quaternized analogue of the heterocyc...

Descripción completa

Detalles Bibliográficos
Autores principales: Ábrányi-Balogh, Péter, Keeley, Aaron, Ferenczy, György G., Petri, László, Imre, Tímea, Grabrijan, Katarina, Hrast, Martina, Knez, Damijan, Ilaš, Janez, Gobec, Stanislav, Keserű, György M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781958/
https://www.ncbi.nlm.nih.gov/pubmed/36558935
http://dx.doi.org/10.3390/ph15121484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781958/
https://www.ncbi.nlm.nih.gov/pubmed/36558935
http://dx.doi.org/10.3390/ph15121484

Ejemplares similares