Thermodynamic Correlation between Liquid–Liquid Phase Separation and Crystalline Solubility of Drug-Like Molecules

The purpose of the present study was to experimentally confirm the thermodynamic correlation between the intrinsic liquid–liquid phase separation (LLPS) concentration ([Formula: see text]) and crystalline solubility ([Formula: see text]) of drug-like molecules. Based on the thermodynamic principles,...

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Detalles Bibliográficos
Autores principales: Uekusa, Taiga, Watanabe, Tomohiro, Watanabe, Daiju, Sugano, Kiyohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782016/
https://www.ncbi.nlm.nih.gov/pubmed/36559054
http://dx.doi.org/10.3390/pharmaceutics14122560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782016/
https://www.ncbi.nlm.nih.gov/pubmed/36559054
http://dx.doi.org/10.3390/pharmaceutics14122560

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