Combination Treatment of Withalongolide a Triacetate with Cisplatin Induces Apoptosis by Targeting Translational Initiation, Migration, and Epithelial to Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma

Treatment regimens for head and neck squamous cell carcinoma (HNSCC) typically include cisplatin and radiotherapy and are limited by toxicities. We have identified naturally derived withalongolide A triacetate (WGA-TA) from Physalis longifolia as a lead compound for targeting HNSCC. We hypothesized...

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Detalles Bibliográficos
Autores principales: Subramanian, Chitra, Spielbauer, Katie K., Pearce, Robin, Kovatch, Kevin J., Prince, Mark E., Timmermann, Barbara N., Cohen, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782118/
https://www.ncbi.nlm.nih.gov/pubmed/36558560
http://dx.doi.org/10.3390/nu14245398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782118/
https://www.ncbi.nlm.nih.gov/pubmed/36558560
http://dx.doi.org/10.3390/nu14245398

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