Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging

Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to assess the brain penetration of crizotinib. Positron emissio...

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Detalles Bibliográficos
Autores principales: Sardana, Malvika, Breuil, Louise, Goutal, Sébastien, Goislard, Maud, Kondrashov, Mikhail, Marchal, Etienne, Besson, Florent L., Dugave, Christophe, Wrigley, Gail, Jonson, Anna C., Kuhnast, Bertrand, Schou, Magnus, Tournier, Nicolas, Elmore, Charles S., Caillé, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782192/
https://www.ncbi.nlm.nih.gov/pubmed/36559018
http://dx.doi.org/10.3390/ph15121568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782192/
https://www.ncbi.nlm.nih.gov/pubmed/36559018
http://dx.doi.org/10.3390/ph15121568

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