Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors

Therapy of FLT3-positive acute myeloid leukemia still remains complicated, despite the availability of newly approved kinase inhibitors. Various strategies to avoid the reduced efficacy of therapy have been explored, including the development of dual targeting compounds, which inhibit FLT3 and anoth...

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Detalles Bibliográficos
Autores principales: Tomanová, Monika, Kozlanská, Karolína, Jorda, Radek, Jedinák, Lukáš, Havlíková, Tereza, Řezníčková, Eva, Peřina, Miroslav, Klener, Pavel, Dolníková, Alexandra, Cankař, Petr, Kryštof, Vladimír
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782245/
https://www.ncbi.nlm.nih.gov/pubmed/36555810
http://dx.doi.org/10.3390/ijms232416169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782245/
https://www.ncbi.nlm.nih.gov/pubmed/36555810
http://dx.doi.org/10.3390/ijms232416169

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