Structure of full-length TSH receptor in complex with antibody K1-70™

Determination of the full-length thyroid-stimulating hormone receptor (TSHR) structure by cryo-electron microscopy (cryo-EM) is described. The TSHR complexed with human monoclonal TSHR autoantibody K1-70™ (a powerful inhibitor of TSH action) was detergent solubilised, purified to homogeneity and ana...

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Detalles Bibliográficos
Autores principales: Núñez Miguel, Ricardo, Sanders, Paul, Allen, Lloyd, Evans, Michele, Holly, Matthew, Johnson, William, Sullivan, Andrew, Sanders, Jane, Furmaniak, Jadwiga, Rees Smith, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782461/
https://www.ncbi.nlm.nih.gov/pubmed/36069797
http://dx.doi.org/10.1530/JME-22-0120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782461/
https://www.ncbi.nlm.nih.gov/pubmed/36069797
http://dx.doi.org/10.1530/JME-22-0120

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