Cargando…
Connexin 30 Deficiency Ameliorates Disease Progression at the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by Suppressing Glial Inflammation
Connexin 30 (Cx30), which forms gap junctions between astrocytes, regulates cell adhesion and migration, and modulates glutamate transport. Cx30 is upregulated on activated astroglia in central nervous system inflammatory lesions, including spinal cord lesions in mutant superoxide dismutase 1 (mSOD1...
Autores principales: | Hashimoto, Yu, Yamasaki, Ryo, Ko, Senri, Matsuo, Eriko, Kobayakawa, Yuko, Masaki, Katsuhisa, Matsuse, Dai, Isobe, Noriko |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782489/ https://www.ncbi.nlm.nih.gov/pubmed/36555685 http://dx.doi.org/10.3390/ijms232416046 |
Ejemplares similares
-
Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy
por: Nishimura, Yuji, et al.
Publicado: (2022) -
Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis
por: Kobayakawa, Yuko, et al.
Publicado: (2018) -
Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model
por: Cui, Yiwen, et al.
Publicado: (2014) -
Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia
por: Fang, Mei, et al.
Publicado: (2018) -
Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression
por: Shiraishi, Wataru, et al.
Publicado: (2021)