PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux

Pleckstrin Homology And RUN Domain Containing M2 (PLEKHM2) [delAG] mutation causes dilated cardiomyopathy with left ventricular non-compaction (DCM-LVNC), resulting in a premature death of PLEKHM2[delAG] individuals due to heart failure. PLEKHM2 is a factor involved in autophagy, a master regulator...

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Detalles Bibliográficos
Autores principales: Ben-Zvi, Hadas, Rabinski, Tatiana, Ofir, Rivka, Cohen, Smadar, Vatine, Gad D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782635/
https://www.ncbi.nlm.nih.gov/pubmed/36555735
http://dx.doi.org/10.3390/ijms232416092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782635/
https://www.ncbi.nlm.nih.gov/pubmed/36555735
http://dx.doi.org/10.3390/ijms232416092

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