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DNA G-Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody

[Image: see text] G-quadruplexes (G4s) are four-stranded DNA secondary structures that occur in the human genome and play key roles in transcription, replication, and genome stability. G4-specific molecular probes are of vital importance to elucidate the structure and function of G4s. The scFv antib...

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Detalles Bibliográficos
Autores principales: Galli, Silvia, Melidis, Larry, Flynn, Sean M., Varshney, Dhaval, Simeone, Angela, Spiegel, Jochen, Madden, Sarah K., Tannahill, David, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782783/
https://www.ncbi.nlm.nih.gov/pubmed/36488193
http://dx.doi.org/10.1021/jacs.2c10656