Risk of Cardiac Lesion with Chronic and Acute Use of Loperamide—An Integrative Review

Loperamide is a synthetic opioid commonly used as an antidiarrheal due to its activation of u-opioid receptors in the myenteric plexus. In therapeutic doses, it inhibits peristalsis and has anti-secretory and anti-motility effects, until metabolized by intestinal and hepatic CYP3A4 and CYP2C8 into i...

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Detalles Bibliográficos
Autores principales: Lammoglia, Bruna Cremonezi, Hasselmann, Gabriela, Pires-Oliveira, Marcelo, Duarte Nicolau, Lucas Antonio, Rolim Medeiros, Jand Venes, Sabia Tallo, Fernando, Omar Taha, Murched, Yamaguti Lima, Rildo, Caricati-Neto, Afonso, Menezes-Rodrigues, Francisco Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782787/
https://www.ncbi.nlm.nih.gov/pubmed/36547428
http://dx.doi.org/10.3390/jcdd9120431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782787/
https://www.ncbi.nlm.nih.gov/pubmed/36547428
http://dx.doi.org/10.3390/jcdd9120431

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