Cargando…

Screening and Identification of Lassa Virus Entry Inhibitors from a Fragment-Based Drug Discovery Library

Lassa virus (LASV) is a highly pathogenic virus that is categorized as a biosafety level-4 pathogen. Currently, there are no approved drugs or vaccines specific to LASV. In this study, high-throughput screening of a fragment-based drug discovery library was performed against LASV entry using a pseud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hou, Yuxia, Liu, Yang, Jia, Xiaoying, Zhou, Minmin, Mao, Wenting, Dong, Siqi, Zhang, Yueli, Xiao, Gengfu, Wang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782912/ https://www.ncbi.nlm.nih.gov/pubmed/36560653 http://dx.doi.org/10.3390/v14122649

Ejemplares similares

Screening and Identification of Lujo Virus Entry Inhibitors From an Food and Drug Administration-Approved Drugs Library
por: Cao, Junyuan, et al.
Publicado: (2021)

Deletion of the first glycosylation site promotes Lassa virus glycoprotein-mediated membrane fusion
por: Dong, Siqi, et al.
Publicado: (2023)

Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug Library
por: Wang, Peilin, et al.
Publicado: (2018)

Screening of Botanical Drugs against Lassa Virus Entry
por: Liu, Yang, et al.
Publicado: (2021)

Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19
por: Cao, Junyuan, et al.
Publicado: (2022)

Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry
por: Tang, Ke, et al.
Publicado: (2020)

Bergamottin, a bioactive component of bergamot, inhibits SARS-CoV-2 infection in golden Syrian hamsters
por: Zhou, Minmin, et al.
Publicado: (2022)

Identification of a clinical compound losmapimod that blocks Lassa virus entry
por: Zhang, Xiaoyu, et al.
Publicado: (2019)

Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2
por: Zhang, Guangshun, et al.
Publicado: (2019)

CP100356 Hydrochloride, a P-Glycoprotein Inhibitor, Inhibits Lassa Virus Entry: Implication of a Candidate Pan-Mammarenavirus Entry Inhibitor
por: Takenaga, Toru, et al.
Publicado: (2021)

Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus
por: Herrador, Antonio, et al.
Publicado: (2019)

The Role of Receptor Tyrosine Kinases in Lassa Virus Cell Entry
por: Fedeli, Chiara, et al.
Publicado: (2020)

Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication
por: Loureiro, María Eugenia, et al.
Publicado: (2019)

Fragment-Based Library Generation for the Discovery of a Peptidomimetic p53-Mdm4 Inhibitor
por: Boltjes, André, et al.
Publicado: (2014)

Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors
por: Keeley, A., et al.
Publicado: (2018)

Fragment Library of Natural Products and Compound Databases for Drug Discovery †
por: Chávez-Hernández, Ana L., et al.
Publicado: (2020)

NMR quality control of fragment libraries for screening
por: Sreeramulu, Sridhar, et al.
Publicado: (2020)

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening
por: Prakash, Ohm, et al.
Publicado: (2019)

Discovery of Novel Dihydrolipoamide S-Succinyltransferase Inhibitors Based on Fragment Virtual Screening
por: Wei, Chengqian, et al.
Publicado: (2021)

Fragment‐based drug discovery—the importance of high‐quality molecule libraries
por: Bon, Marta, et al.
Publicado: (2022)

Effects of N-Linked Glycan on Lassa Virus Envelope Glycoprotein Cleavage, Infectivity, and Immune Response
por: Zhu, Xueqin, et al.
Publicado: (2021)

Discovery of a Novel Acetylcholinesterase Inhibitor by Fragment-Based Design and Virtual Screening
por: Stavrakov, Georgi, et al.
Publicado: (2021)

Identification of candidate genes with pro-apoptotic properties by functional screening of randomly fragmented CDNA libraries
por: Hassan, M, et al.
Publicado: (2010)

Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein
por: Zhu, Shenglin, et al.
Publicado: (2019)

The sensitivity and specificity of Lassa virus IgM by ELISA as screening tool at early phase of Lassa fever infection
por: Ibekwe, Titus S., et al.
Publicado: (2012)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library
por: Woodland, Andrew, et al.
Publicado: (2015)

Discovery of Survivin Inhibitors Part 1: Screening the Harbor Branch Pure Compound Library
por: Guzmán, Esther A., et al.
Publicado: (2021)

Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors
por: Zhang, Xuejiao, et al.
Publicado: (2019)

GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus
por: Chen, Danying, et al.
Publicado: (2019)

Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1
por: Wang, May Kwang-Mei, et al.
Publicado: (2018)

Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin
por: Yang, Jie, et al.
Publicado: (2013)

Screening of Natural Extracts for Inhibitors against Japanese Encephalitis Virus Infection
por: Guo, Jiao, et al.
Publicado: (2020)

Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
por: He, Chang-Long, et al.
Publicado: (2021)

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments
por: Moghaddam-Taaheri, Parisa, et al.
Publicado: (2016)

Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening
por: Chopra, Ashima, et al.
Publicado: (2023)

Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening
por: Hoarau, Marie, et al.
Publicado: (2021)

Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides
por: Trinh, Thi B., et al.
Publicado: (2015)

Discovery of novel elongator protein 2 inhibitors by compound library screening using surface plasmon resonance
por: Xu, Chang-Peng, et al.
Publicado: (2019)

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
por: Resnick, Efrat, et al.
Publicado: (2019)

Pathogenesis of Lassa Fever
por: Yun, Nadezhda E., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8no9hc2fc694cdis7ccd776gm1