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Substrate Recognition Properties from an Intermediate Structural State of the UreA Transporter
Through a combination of comparative modeling, site-directed and classical random mutagenesis approaches, we previously identified critical residues for binding, recognition, and translocation of urea, and its inhibition by 2-thiourea and acetamide in the Aspergillus nidulans urea transporter, UreA....
Autores principales: | Sanguinetti, Manuel, Silva Santos, Lucianna Helene, Dourron, Juliette, Alamón, Catalina, Idiarte, Juan, Amillis, Sotiris, Pantano, Sergio, Ramón, Ana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783183/ https://www.ncbi.nlm.nih.gov/pubmed/36555682 http://dx.doi.org/10.3390/ijms232416039 |
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