Cargando…

New Derivatives of the Multi-Stage Active Malaria Box Compound MMV030666 and Their Antiplasmodial Potencies

MMV’s Malaria Box compound MMV030666 shows multi-stage activity against various strains of Plasmodium falciparum and lacks resistance development. To evaluate the importance of its diarylether partial structure, diarylthioethers and diphenylamines with varying substitution patterns were prepared. A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hermann, Theresa, Wallner, Robin, Dolensky, Johanna, Seebacher, Werner, Pferschy-Wenzig, Eva-Maria, Kaiser, Marcel, Mäser, Pascal, Weis, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783227/ https://www.ncbi.nlm.nih.gov/pubmed/36558954 http://dx.doi.org/10.3390/ph15121503

Ejemplares similares

Structure–Activity Relationships and Antiplasmodial Potencies of Novel 3,4-Disubstituted 1,2,5-Oxadiazoles
por: Hochegger, Patrick, et al.
Publicado: (2023)

Synthesis and Structure-Activity Relationships of New 2-Phenoxybenzamides with Antiplasmodial Activity
por: Hermann, Theresa, et al.
Publicado: (2021)

New Acyl Derivatives of 3-Aminofurazanes and Their Antiplasmodial Activities
por: Hermann, Theresa, et al.
Publicado: (2021)

8-Amino-6-Methoxyquinoline—Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity
por: Hochegger, Patrick, et al.
Publicado: (2021)

Synthesis and Antiprotozoal Activity of Azabicyclo-Nonane Pyrimidine Hybrids
por: Hinteregger, Clemens, et al.
Publicado: (2022)

Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores
por: Dolensky, Johanna, et al.
Publicado: (2022)

Identification of β-hematin inhibitors in the MMV Malaria Box
por: Fong, Kim Y., et al.
Publicado: (2015)

Efficient Oxidative Dearomatisations of Substituted Phenols Using Hypervalent Iodine (III) Reagents and Antiprotozoal Evaluation of the Resulting Cyclohexadienones against T. b. rhodesiense and P. falciparum Strain NF54
por: Scheiber, Nina, et al.
Publicado: (2022)

Formation of 5-Aminomethyl-2,3-dihydropyridine-4(1H)-ones from 4-Amino-tetrahydropyridinylidene Salts
por: Seebacher, Werner, et al.
Publicado: (2023)

Identification of MMV Malaria Box Inhibitors of Perkinsus marinus Using an ATP-Based Bioluminescence Assay
por: Alemán Resto, Yesmalie, et al.
Publicado: (2014)

Actives from MMV Open Access Boxes? A suggested way forward
por: Samby, Kirandeep, et al.
Publicado: (2021)

Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei
por: Dize, Darline, et al.
Publicado: (2022)

Discovery of New Chemical Tools against Leishmania amazonensis via the MMV Pathogen Box
por: López-Arencibia, Atteneri, et al.
Publicado: (2021)

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
por: Reader, Janette, et al.
Publicado: (2021)

MMV in partnership: the Eurartesim(®) experience
por: Ubben, David, et al.
Publicado: (2013)

In Vitro Activities of MMV Malaria Box Compounds against the Apicomplexan Parasite Neospora caninum, the Causative Agent of Neosporosis in Animals
por: Müller, Joachim, et al.
Publicado: (2020)

A screening of the MMV Pathogen Box® reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis
por: Coelho, Rowena Alves, et al.
Publicado: (2020)

Diaminoquinazoline MMV675968 from Pathogen Box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase
por: Songsungthong, Warangkhana, et al.
Publicado: (2019)

MMV560185 from pathogen box induces extrinsic pathway of apoptosis in Theileria annulata infected bovine leucocytes
por: Araveti, Prasanna Babu, et al.
Publicado: (2022)

Stepwise in vitro screening of MMV pathogen box compounds against Plasmodium falciparum to identify potent antimalarial candidates
por: Mbye, Haddijatou, et al.
Publicado: (2023)

Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screen
por: Ahyong, Vida, et al.
Publicado: (2016)

A Screening of the MMV Pandemic Response Box Reveals Epetraborole as A New Potent Inhibitor against Mycobacterium abscessus
por: Kim, Taeho, et al.
Publicado: (2021)

New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box(®) that present synergism with itraconazole
por: Coelho, Rowena Alves, et al.
Publicado: (2022)

Efficacy, Safety, Tolerability, and Pharmacokinetics of MMV390048 in Acute Uncomplicated Malaria
por: Mohammed, Rezika, et al.
Publicado: (2023)

Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box on Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii
por: Rice, Christopher A., et al.
Publicado: (2020)

Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides
por: Vermeer, Louic S., et al.
Publicado: (2012)

Screening of MMV pandemic response and pathogen box compounds against pan-drug-resistant Klebsiella pneumoniae to identify potent inhibitory compounds
por: Sivasankar, Seshan, et al.
Publicado: (2023)

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
por: de Vries, Laura E., et al.
Publicado: (2022)

Does a Graphical Abstract Bring More Visibility to Your Paper?
por: Pferschy-Wenzig, Eva-Maria, et al.
Publicado: (2016)

Erratum: Pferschy-Wenzig, E.-M.; et al. Does a Graphical Abstract Bring More Visibility to Your Paper? Molecules 2016, 21, 1247
por: Pferschy-Wenzig, Eva-Maria, et al.
Publicado: (2016)

Repurposing the Medicines for Malaria Venture’s COVID Box to discover potent inhibitors of Toxoplasma gondii, and in vivo efficacy evaluation of almitrine bismesylate (MMV1804175) in chronically infected mice
por: dos Santos, Bruna Ramos, et al.
Publicado: (2023)

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds
por: Spavieri, Jasmine, et al.
Publicado: (2013)

Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies
por: de Souza, Guilherme Eduardo, et al.
Publicado: (2019)

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics
por: Ghidelli-Disse, Sonja, et al.
Publicado: (2014)

Screening of the Pandemic Response Box Reveals an Association between Antifungal Effects of MMV1593537 and the Cell Wall of Cryptococcus neoformans, Cryptococcus deuterogattii, and Candida auris
por: de Oliveira, Haroldo C., et al.
Publicado: (2022)

Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi
por: Rocha-Hasler, Marianne, et al.
Publicado: (2021)

Antibacterial and Antibiofilm Properties of the Alexidine Dihydrochloride (MMV396785) against Acinetobacter baumannii
por: Upmanyu, Kirti, et al.
Publicado: (2023)

A Combined LC-MS Metabolomics- and 16S rRNA Sequencing Platform to Assess Interactions between Herbal Medicinal Products and Human Gut Bacteria in Vitro: a Pilot Study on Willow Bark Extract
por: Pferschy-Wenzig, Eva-Maria, et al.
Publicado: (2017)

Characterization of Three Novel 4-Methylaminorex Derivatives Applied as Designer Drugs
por: Seibert, Elisabeth, et al.
Publicado: (2022)

Antiplasmodial Natural Products
por: Nogueira, Cláudio R., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_1lb6f4hf6mh36g1e06kn3bii6q