Disruption of the NKG2A:HLA-E Immune Checkpoint Axis to Enhance NK Cell Activation against Cancer

Ligation of the inhibitory receptor NKG2A by its ligand HLA-E negatively regulates the activation of natural killer (NK) cells, as well as subsets of CD8+ T cells and innate T cell populations. NKG2A has recently become a novel immune checkpoint target for the treatment of cancer and direct antibody...

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Detalles Bibliográficos
Autores principales: Fisher, Jack G., Doyle, Amber D. P., Graham, Lara V., Khakoo, Salim I., Blunt, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783329/
https://www.ncbi.nlm.nih.gov/pubmed/36560403
http://dx.doi.org/10.3390/vaccines10121993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783329/
https://www.ncbi.nlm.nih.gov/pubmed/36560403
http://dx.doi.org/10.3390/vaccines10121993

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