Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis

Background: The current study utilizes in silico molecular docking/molecular dynamics to evaluate the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR, followed by assessment of in vivo effects of these compounds on depressive and anxious behavior. Methods: The docking between apigenin a...

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Detalles Bibliográficos
Autores principales: Amin, Faiq, Ibrahim, Mahmoud A. A., Rizwan-ul-Hasan, Syed, Khaliq, Saima, Gabr, Gamal A., Muhammad, Khan, Asra, Sidhom, Peter A., Tikmani, Prashant, Shawky, Ahmed M., Ahmad, Saara, Abidi, Syed Hani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783496/
https://www.ncbi.nlm.nih.gov/pubmed/36557792
http://dx.doi.org/10.3390/molecules27248658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783496/
https://www.ncbi.nlm.nih.gov/pubmed/36557792
http://dx.doi.org/10.3390/molecules27248658

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