Usnic Acid-Mediated Exchange of Protons for Divalent Metal Cations across Lipid Membranes: Relevance to Mitochondrial Uncoupling

Usnic acid (UA), a unique lichen metabolite, is a protonophoric uncoupler of oxidative phosphorylation, widely known as a weight-loss dietary supplement. In contrast to conventional proton-shuttling mitochondrial uncouplers, UA was found to carry protons across lipid membranes via the induction of a...

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Detalles Bibliográficos
Autores principales: Rokitskaya, Tatyana I., Arutyunyan, Alexander M., Khailova, Ljudmila S., Kataeva, Alisa D., Firsov, Alexander M., Kotova, Elena A., Antonenko, Yuri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783568/
https://www.ncbi.nlm.nih.gov/pubmed/36555847
http://dx.doi.org/10.3390/ijms232416203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783568/
https://www.ncbi.nlm.nih.gov/pubmed/36555847
http://dx.doi.org/10.3390/ijms232416203

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