Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo

In order to enable (18)F- and (177)Lu-labelling within the same molecule, we introduced a silicon-based fluoride acceptor (SiFA) into the hexa-D-glutamate chain of DOTA-PP-F11N. In addition, minigastrin analogues with a prolonged as well as γ-linked D-glutamate chain were synthesised and evaluated....

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Detalles Bibliográficos
Autores principales: Holzleitner, Nadine, Günther, Thomas, Beck, Roswitha, Lapa, Constantin, Wester, Hans-Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783573/
https://www.ncbi.nlm.nih.gov/pubmed/36558917
http://dx.doi.org/10.3390/ph15121467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783573/
https://www.ncbi.nlm.nih.gov/pubmed/36558917
http://dx.doi.org/10.3390/ph15121467

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