Atroposelective Amination of Indoles via Chiral Center Induced Chiral Axis Formation

The construction of an N–C chiral axis for N-aryl indole derivatives is meaningful as they widely exist in functionalized molecules. This work provides a novel method for this purpose via amination of amino acid derivatives at the C2 position of the indole and chiral center induced chiral axis forma...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Yan, Jingxue, Jiang, Yiqing, Wei, Zexuan, Tu, Zhenlin, Dong, Chao, Lu, Tao, Chen, Yadong, Feng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783779/
https://www.ncbi.nlm.nih.gov/pubmed/36558141
http://dx.doi.org/10.3390/molecules27249008
Descripción
Sumario:The construction of an N–C chiral axis for N-aryl indole derivatives is meaningful as they widely exist in functionalized molecules. This work provides a novel method for this purpose via amination of amino acid derivatives at the C2 position of the indole and chiral center induced chiral axis formation. The protocol of this transformation is easily accessible, not requiring metal or an organic chiral catalyst, endowing this method with great potential in the construction of axis chiral N-aryl indoles.

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