Indoline-5-Sulfonamides: A Role of the Core in Inhibition of Cancer-Related Carbonic Anhydrases, Antiproliferative Activity and Circumventing of Multidrug Resistance

The overexpression and activity of carbonic anhydrase (CA, EC 4.2.1.1) isoforms CA IX and CA XII promote the accumulation of exceeding protons and acidosis in the extracellular tumor environment. Sulfonamides are effective inhibitors of most families of CAs. In this study, using scaffold-hopping, in...

Descripción completa

Detalles Bibliográficos
Autores principales: Krymov, Stepan K., Scherbakov, Alexander M., Dezhenkova, Lyubov G., Salnikova, Diana I., Solov’eva, Svetlana E., Sorokin, Danila V., Vullo, Daniela, De Luca, Viviana, Capasso, Clemente, Supuran, Claudiu T., Shchekotikhin, Andrey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783868/
https://www.ncbi.nlm.nih.gov/pubmed/36558903
http://dx.doi.org/10.3390/ph15121453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783868/
https://www.ncbi.nlm.nih.gov/pubmed/36558903
http://dx.doi.org/10.3390/ph15121453

Ejemplares similares